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Published on: October 10, 2025
Lineage Specifiers in Lung Cancer Are Ahead of Their TIME
Kelli A Connolly1, Brittany Fitzgerald1, Nikhil S Joshi1
1Yale University School of Medicine, Department of Immunobiology, New Haven, CT 06519, USA.
Abstract:
The factors that shape the distinctive tumor-immune landscapes of various types and subtypes of cancer remain poorly understood. In this issue of Immunity, Mollaoglu et al. (2018) reveal a mechanistic link between the function of lineage specifiers SOX2 and NKX2-1 and the presence of neutrophils in the tumor-immune microenvironment of lung cancer.
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