Related Experiment Video
Updated: Feb 3, 2026
11:52
Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
Published on: January 27, 2023
4.5K
Developmental and Functional Heterogeneity of Monocytes
Martin Guilliams1, Alexander Mildner2, Simon Yona3
1Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Center for Inflammation Research, Technologiepark 927, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Immunity
|October 18, 2018
Summary
Recent advances reveal monocyte heterogeneity, with distinct subsets and developmental paths. These insights redefine monocyte roles in health, inflammation, and tissue repair, highlighting new research perspectives.
Area of Science:
- Immunology
- Hematology
- Cell Biology
Background:
- Monocyte development and function have been redefined by novel experimental approaches.
- Monocytes are now understood to comprise multiple subsets with distinct developmental origins and specialized functions.
Purpose of the Study:
- To outline emerging concepts in monocyte heterogeneity, emergency monopoiesis, and trained immunity.
- To discuss new perspectives these concepts bring to monocyte research.
Main Methods:
- Fate-mapping techniques.
- Single-cell analysis.
Main Results:
- Monocytes exhibit heterogeneity with diverse functional specializations.
- Under homeostatic conditions, monocytes accumulate in peripheral reservoirs or engraft into resident macrophage pools.
- During inflammation, recruited monocytes display distinct effector and regulatory functions, differing from resident macrophages and dendritic cells.
Conclusions:
- Emerging concepts like monocyte heterogeneity, emergency monopoiesis, and trained immunity offer new perspectives in monocyte research.
- Understanding monocyte subsets and their dynamic roles is crucial for comprehending immune responses and tissue homeostasis.
Related Concept Videos
01:27Introduction to Developmental Psychology
1.5K
Developmental psychology explores the changes and continuities in human abilities throughout life, encompassing physical, cognitive, linguistic, and social dimensions. Human development is not restricted to growth, but includes aspects of decline, particularly in physical abilities as individuals age. Developmental psychologists seek to understand how people change as they age and how their mental and social skills evolve.Developmental MilestonesA key concept in developmental psychology is...
1.5K
01:29Three Developmental Domains
1.1K
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
1.1K
02:45Functional Groups
88.6K
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
88.6K
02:45Functional Groups
24.4K
24.4K
01:11Functionalism
2.6K
William James, John Dewey, and Charles Sanders Peirce were instrumental in founding functional psychology, which draws heavily from Darwin's theory of evolution by natural selection. This theory suggests that individual traits, including behaviors, are adapted to their environments through natural selection. At the heart of functionalism is the concept of adaptation, meaning that a trait enhances an individual's chances of survival and reproduction.
James envisioned psychology's...
James envisioned psychology's...
2.6K
01:58Mechanical Protein Functions
5.6K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.
5.6K