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ZFLNC: a comprehensive and well-annotated database for zebrafish lncRNA.
Xiang Hu1,2, Wen Chen1,2, Jing Li1
1CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, China.
Database : the Journal of Biological Databases and Curation
|October 19, 2018
Summary
This study introduces ZFLNC, a comprehensive database for zebrafish long non-coding RNAs (lncRNAs). It offers a platform for exploring zebrafish lncRNAs and their mammalian counterparts, aiding biological research.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Long non-coding RNAs (lncRNAs) play crucial roles in biological processes.
- Zebrafish are a valuable model organism for studying lncRNA function and mechanisms.
- A dedicated resource for zebrafish lncRNAs is needed for comprehensive research.
Purpose of the Study:
- To construct ZFLNC, a comprehensive database for zebrafish long non-coding RNAs (lncRNAs).
- To provide a platform for exploring zebrafish lncRNAs and their mammalian counterparts.
- To facilitate deep exploration of lncRNA functions and mechanisms in zebrafish.
Main Methods:
- Collected lncRNA data from NCBI, Ensembl, NONCODE, zflncRNApedia, literature, and SRA RNA-Seq datasets.
- Performed expression profiling and co-expression network prediction for identified lncRNAs.
- Conducted Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Online Mendelian Inheritance in Man (OMIM) annotation, and conservation analysis.
Main Results:
- Developed ZFLNC, a comprehensive and well-annotated database for zebrafish lncRNAs.
- Integrated diverse data sources for extensive lncRNA coverage.
- Provided functional annotations and conservation information for zebrafish lncRNAs.
Conclusions:
- ZFLNC serves as the most comprehensive resource for zebrafish lncRNAs to date.
- The database facilitates in-depth research into zebrafish lncRNA biology.
- ZFLNC supports comparative studies between zebrafish and mammalian lncRNAs.
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