Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...

The Tree of Life - Bacteria, Archaea, Eukaryotes

The Tree of Life - Bacteria, Archaea, Eukaryotes

The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Colonic dysmotility in children with functional constipation and psychiatric and developmental disorders.

Journal of pediatric gastroenterology and nutrition·2026

Same author

Introducing new technology to your pediatric gastroenterology practice: Navigating the business side of healthcare.

Journal of pediatric gastroenterology and nutrition·2026

Same author

Rumination syndrome and eosinophilic esophagitis in children: Defining the relationship.

Journal of pediatric gastroenterology and nutrition·2026

Same author

The rumination severity index: Development and evaluation of a scoring tool for rumination syndrome.

Journal of pediatric gastroenterology and nutrition·2026

Same author

Antegrade continence enema treatment can lead to proximal colonic dilation while preserving motility in children with constipation.

Journal of pediatric surgery·2026

Same author

Interrater reliability in pediatric high-resolution anorectal manometry recordings.

Journal of pediatric gastroenterology and nutrition·2026

Same journal

Living Donor Intestinal and Liver Transplantation.

Gastroenterology clinics of North America·2026

Same journal

Living Abdominal Organ Donation: A Plan B That Saves Lives.

Gastroenterology clinics of North America·2026

Same journal

Long-Term Outcomes of Living Liver Donors.

Gastroenterology clinics of North America·2026

Same journal

Perioperative Management of Living Liver Donor Patients.

Gastroenterology clinics of North America·2026

Same journal

Living Donor Liver Transplantation for Colorectal Cancer Liver Metastasis.

Gastroenterology clinics of North America·2026

Same journal

Living Donor Liver Graft in Adult Populations: Donor Selection and Workup.

Gastroenterology clinics of North America·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 3, 2026

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

Constipation: Beyond the Old Paradigms.

Peter L Lu¹, Hayat M Mousa²

¹Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

Gastroenterology Clinics of North America

|October 20, 2018

Summary

This summary is machine-generated.

Refractory constipation in children may stem from evacuation or motility disorders. Advanced diagnostics and treatments like novel medications, biofeedback, and surgery offer solutions for persistent pediatric constipation.

Keywords:

Antegrade continence enema Children Defecation disorder Encopresis Fecal incontinence Pediatrics Sacral nerve stimulation Sacral neuromodulation

More Related Videos

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

The HoneyComb Paradigm for Research on Collective Human Behavior

The HoneyComb Paradigm for Research on Collective Human Behavior

Published on: January 19, 2019

Related Experiment Videos

Last Updated: Feb 3, 2026

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

The HoneyComb Paradigm for Research on Collective Human Behavior

The HoneyComb Paradigm for Research on Collective Human Behavior

Published on: January 19, 2019

Area of Science:

Pediatric Gastroenterology
Colorectal Surgery

Background:

Constipation is a prevalent issue in pediatric populations.
A subset of children experience persistent symptoms despite conventional therapies.

Purpose of the Study:

To outline diagnostic and management strategies for pediatric refractory constipation.
To highlight advanced interventions for complex cases.

Main Methods:

Anorectal and colonic manometry to diagnose rectal evacuation or colonic motility disorders.
Review of novel medications, biofeedback, botulinum toxin injections, antegrade continence enemas, sacral nerve stimulation, and colonic resection.

Main Results:

Manometry effectively identifies specific functional disorders.
Emerging pharmacologic and therapeutic options show promise in pediatric use.
Surgical interventions provide options for intractable cases.

Conclusions:

Accurate diagnosis via manometry is crucial for guiding treatment in refractory pediatric constipation.
A multimodal approach, including novel medications and interventions, is essential for managing complex cases.