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Advances in Pediatric Fatty Liver Disease: Pathogenesis, Diagnosis, and Treatment

Hayley A Braun1, Sarah A Faasse2, Miriam B Vos2

  • 1Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive North East, Atlanta, GA 30322, USA.

Gastroenterology Clinics of North America
|October 20, 2018
PubMed

Insights

Pediatric nonalcoholic fatty liver disease (NAFLD) is rising, with unclear causes and limited treatments. Recent research improves understanding of NAFLD pathophysiology, diagnostics, and therapies for children.

Area of Science:

  • Hepatology
  • Pediatric Gastroenterology
  • Metabolic Disorders

Background:

  • Pediatric nonalcoholic fatty liver disease (NAFLD) represents a growing global health concern.
  • Current understanding of NAFLD pathophysiology in children remains incomplete.
  • Existing diagnostic methods for pediatric NAFLD are often invasive, and therapeutic strategies are limited.

Purpose of the Study:

  • To review recent advancements in understanding the pathophysiology of pediatric NAFLD.
  • To discuss the development of less invasive diagnostic tools for pediatric NAFLD.
  • To highlight emerging therapeutic options and ongoing clinical trials for children with NAFLD.

Main Methods:

  • Literature review of recent studies on pediatric NAFLD.
  • Analysis of emerging diagnostic technologies.
  • Survey of current and upcoming therapeutic interventions.

Main Results:

  • Significant progress has been made in elucidating the complex pathophysiology of pediatric NAFLD.
  • New, less invasive diagnostic modalities are becoming available.
  • Several promising therapeutic strategies are under investigation in clinical trials.

Conclusions:

  • Continued research is crucial for advancing the diagnosis and treatment of pediatric NAFLD.
  • Improved understanding of pathophysiology aids in developing targeted therapies.
  • Emerging treatments offer hope for better management of this prevalent childhood liver disease.

Keywords:
DiagnosisPediatric NAFLDReviewTreatmentType II diabetes

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