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[Andrology in oncological diseases].

T Weberschock1,2, S Grunewald3, F Ochsendorf4

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Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|October 25, 2018
PubMed
Summary

Dermato-oncology treatments can impact male fertility. Early discussion and options like sperm or testicular tissue cryopreservation offer simple, safe fertility preservation for cancer patients.

Keywords:
CancerCryopreservationDermatologyFertilityOncology

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Area of Science:

  • Dermato-oncology
  • Reproductive Medicine
  • Oncology

Background:

  • Dermato-oncological treatments frequently involve gonadotoxic interventions.
  • Alkylating agents, hormonal therapies, and gonadal irradiation can limit male fertility.
  • German guidelines mandate fertility preservation counseling in certified skin cancer centers since 2017.

Purpose of the Study:

  • To emphasize the importance of discussing fertility preservation with male patients undergoing dermato-oncological treatment.
  • To highlight available fertility protection options for men.
  • To inform about new possibilities for cryopreservation in prepubertal males.

Main Methods:

  • Review of current dermato-oncological guidelines and fertility preservation recommendations.
  • Discussion of cryopreservation techniques for ejaculates and testicular tissue.
  • Consideration of hormonal replacement therapy for hypogonadism.

Main Results:

  • Fertility preservation through sperm or testicular tissue cryopreservation is a simple and safe option.
  • The Androprotect project now enables testicular tissue cryopreservation for prepubertal males.
  • Testosterone therapy for hypogonadism requires careful consideration of its anabolic and immunomodulating effects.

Conclusions:

  • Proactive questioning about the desire for children is crucial at relevant stages of treatment.
  • Cryopreservation offers a standardized and accessible method for male fertility protection.
  • Management of treatment-induced hypogonadism necessitates a balanced approach to testosterone therapy.