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[THE COMBINED THERAPY IN HYPERTENSIVE PATIENTS WITH DYSLIPIDEMIA]

R Tabukashvili1, V Kapetivadze1, K Tchaava1

  • 1Tbilisi, State Medical University, Department of Propedeutics of Internal Deseases, Georgia.

Georgian Medical News
|October 26, 2018
PubMed

Insights

Combined therapy with Exforge and fibrates effectively lowers blood pressure and improves lipid profiles in hypertensive patients with dyslipidemia. This treatment strategy offers significant benefits for cardiovascular health management.

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Background:

  • Hypertension and dyslipidemia are significant risk factors for cardiovascular disease.
  • Combined therapy aims to address both conditions simultaneously for improved patient outcomes.

Purpose of the Study:

  • To evaluate the clinical efficacy of combined therapy using Amlodipine/Valsartan (Exforge) with fibrates in hypertensive patients with dyslipidemia.
  • To assess the impact on blood pressure control and lipid profile parameters.

Main Methods:

  • A study involving 58 hypertensive patients (aged 40-65) with dyslipidemia, divided into three groups.
  • Treatment regimens included Amlodipine with Fenofibrate, Exforge with Fenofibrate, and Exforge alone over a 4-month period.
  • Parameters monitored included blood pressure, heart rate, BMI, and lipid profiles (Total Cholesterol, Triglycerides, HDL, LDL).

Main Results:

  • Group 3 (Exforge alone) showed a significant reduction in systolic blood pressure (26.6%) and diastolic blood pressure (18.0%).
  • This group also demonstrated significant improvements in lipid profiles, with decreased Total Cholesterol (-14.5%), Triglycerides (-15.9%), and LDL (-20.2%).
  • Combined therapy with Exforge and fibrates proved effective in managing both hypertension and dyslipidemia.

Conclusions:

  • Combination therapy involving Exforge and fibrates is a clinically effective strategy for hypertensive patients with dyslipidemia.
  • This approach leads to substantial improvements in blood pressure control and lipid parameters, contributing to better cardiovascular risk management.

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