Related Experiment Video
Updated: Feb 3, 2026
10:34
A High-content Assay for Monitoring AMPA Receptor Trafficking
Published on: January 28, 2019
8.1K
The AMPA Receptor Code of Synaptic Plasticity
Graham H Diering1, Richard L Huganir2
1Department of Cell Biology and Physiology, and Neuroscience Center, University of North Carolina, Chapel Hill, NC 27514, USA.
Neuron
|October 26, 2018
Summary
Synaptic plasticity relies on AMPA-type glutamate receptors (AMPARs). The "AMPAR code" framework suggests specific AMPAR variants predict plasticity types and extent, influencing synapse computation.
Area of Science:
- Neuroscience
- Molecular Biology
- Synaptic Plasticity
Background:
- AMPA-type glutamate receptors (AMPARs) mediate synaptic plasticity, including LTP and LTD.
- AMPAR function and trafficking are regulated by subunits, interactors, and modifications.
Purpose of the Study:
- To review the role of AMPAR variants in synaptic plasticity.
- To propose the "AMPAR code" as a conceptual framework.
Main Methods:
- Literature review of AMPAR function and synaptic plasticity.
- Conceptual framework development.
Main Results:
- AMPAR variants, including GluA1-GluA4 subunits, dictate synaptic plasticity.
- Interactions and modifications add regulatory layers to AMPARs.
- The "AMPAR code" framework links specific AMPARs to plasticity types.
Conclusions:
- AMPAR variants are key determinants of synaptic plasticity.
- The "AMPAR code" predicts plasticity based on AMPAR composition.
- A hierarchy of AMPAR recruitment/removal underlies plasticity.
Related Concept Videos
01:12Synaptic Signaling
79.5K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
79.5K
02:39lncRNA - Long Non-coding RNAs
9.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
02:39lncRNA - Long Non-coding RNAs
3.7K
3.7K
00:58Plasticity
3.1K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
3.1K
01:31Plasticizers
368
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
368
01:21Plastic Behavior
579
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
579