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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

852
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
852
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.8K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.7K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

818
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
818
Bone Structure01:55

Bone Structure

51.7K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.7K
Bone Remodeling01:40

Bone Remodeling

40.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.4K

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Related Experiment Video

Updated: Feb 3, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

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Drug Delivery and Bone Infection.

María Vallet-Regí1, Montserrat Colilla1, Isabel Izquierdo-Barba1

  • 1Department of Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense de Madrid and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.

The Enzymes
|October 27, 2018
PubMed
Summary

Silica mesoporous materials (SMMs) offer innovative solutions for bone infection management. These advanced biomaterials exhibit anti-infective properties, including bacteria repulsion, bactericidal effects, and antibiofilm capabilities.

Keywords:
Bacteria targetingBacterial adhesion inhibitionBiocompatibilityBiofilm targetingDrug delivery mesoporous materialsHierarchical 3D meso-macro scaffoldsMesoporous silica nanoparticlesNon-fouling propertiesPreventing and treatment of bone infectionTargeting therapyZwitterionic mesoporous materials

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Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
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Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
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Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

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Last Updated: Feb 3, 2026

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Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
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Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

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Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
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Area of Science:

  • Biomaterials Science
  • Infectious Diseases
  • Nanotechnology

Background:

  • Bone infections pose significant public health challenges with severe socioeconomic consequences.
  • Developing effective treatments for bone infections is a critical area of research.
  • Current strategies often struggle with efficacy and long-term management.

Purpose of the Study:

  • To survey innovative approaches using silica mesoporous materials (SMMs) for managing bone infections.
  • To explore SMMs' potential in combating bacterial colonization and biofilm formation.
  • To review SMM-based strategies for preventing and treating bone infections.

Main Methods:

  • Review of scientific literature on silica mesoporous materials (SMMs) for bone infection management.
  • Analysis of SMMs' anti-infective properties: non-fouling, bactericidal, and antibiofilm.
  • Examination of different SMM-based strategies, including zwitterionization, local antimicrobial delivery, and targeted nanocarriers.

Main Results:

  • Silica mesoporous materials (SMMs) demonstrate versatile anti-infective properties.
  • Zwitterionization creates bacteria-repelling surfaces.
  • Implantable devices with SMMs can deliver antimicrobial agents locally.
  • Targeted nanocarriers based on SMMs show promise for antibiofilm effects.

Conclusions:

  • Silica mesoporous materials (SMMs) represent a promising frontier in bone infection management.
  • SMMs offer multiple mechanisms to combat bone infections, from surface modification to targeted drug delivery.
  • Further research into SMMs can lead to advanced biomaterials for improved patient outcomes.