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The roles of FOX proteins in virus-associated cancers

Ali Ramezani1,2, Hojatolla Nikravesh2,3, Ebrahim Faghihloo4

  • 1Department of Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Journal of Cellular Physiology
|October 27, 2018
PubMed

Insights

Oncoviruses deregulate Forkhead box (FOX) proteins, impacting cancer progression and drug resistance. Targeting FOX proteins offers potential therapeutic strategies for virus-induced cancers.

Area of Science:

  • Molecular Biology
  • Oncology
  • Virology

Background:

  • Forkhead box (FOX) proteins regulate critical cellular processes including metabolism, development, and apoptosis.
  • Deregulation of FOX proteins is linked to cancer initiation, progression, and drug resistance.

Purpose of the Study:

  • To review how oncoviruses deregulate FOX proteins.
  • To explore the mechanisms and consequences of FOX protein deregulation by viruses.

Main Methods:

  • Literature review of oncovirus-host interactions.
  • Analysis of molecular mechanisms of FOX protein deregulation.
  • Examination of signaling pathways affected by oncoviruses.

Main Results:

  • Oncoviruses alter FOX protein posttranslational modifications, localization, and signaling pathways.
  • Deregulation contributes to proliferation, metastasis, chemotherapy resistance, and immunosuppression in virus-induced cancers.
  • PI3K/Akt/mTOR pathway modulation impacts FOXO function and viral infection recovery.

Conclusions:

  • FOX proteins are key players in virus-induced cancers.
  • FOX proteins can serve as prognostic markers.
  • Targeting FOX proteins presents a therapeutic avenue for oncovirus-driven malignancies.
Keywords:
cancerforkhead box proteinsviruses

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