Related Experiment Video
Updated: Feb 3, 2026
06:04
Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
Published on: August 16, 2024
1.6K
Predicting progression in the late onset frontal lobe syndrome
Flora T Gossink1, Everard Vijverberg2, Welmoed Krudop2
1Department of Old Age Psychiatry,GGZinGeest/VU University Medical Center,Amsterdam,the Netherlands.
International Psychogeriatrics
|October 27, 2018
Summary
Predicting the progression of late onset frontal lobe syndrome (LOF) is crucial. Stereotypy and executive deficits predict progression, while psychiatric history predicts stability in LOF patients.
Area of Science:
- Neurology
- Geriatrics
- Behavioral Science
Background:
- Late onset frontal lobe syndrome (LOF) presents diagnostic challenges.
- Reliable progression predictors are needed for clinical guidance in LOF.
- LOF involves apathy, disinhibition, or stereotypical behaviors in adulthood.
Purpose of the Study:
- To identify reliable predictors of disease progression in late onset frontal lobe syndrome.
- To differentiate progressive LOF from non-progressive or treatable conditions.
Main Methods:
- A longitudinal, multicenter, prospective study of 137 LOF patients.
- Assessed progression via institutionalization, death, or MRI atrophy after two years.
- Utilized Frontal Behavior Inventory (FBI) and Stereotypy Rating Inventory (SRI) scores.
Main Results:
- Stereotypy and executive deficits at baseline predicted LOF progression.
- Psychiatric history and family psychiatric history predicted non-progression.
- Combined clinical markers achieved 80.4% predictive value for progression (p < 0.05).
Conclusions:
- Detailed clinical symptom mapping aids in appraising LOF deterioration rates.
- Distinguishing progressive LOF from non-progressive conditions is feasible.
- Clinical markers can guide management and prognosis for LOF patients.
Related Concept Videos
01:22Lobes of the Cerebrum
4.7K
The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
4.7K
02:27Predicting Molecular Geometry
45.8K
VSEPR Theory for Determination of Electron Pair Geometries
45.8K
01:03Prediction Intervals
3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
3.4K
02:07Tumor Progression
7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
01:07End Point Prediction: Gran Plot
1.2K
A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
For potentiometric titration, the Gran plot is created by plotting...
For potentiometric titration, the Gran plot is created by plotting...
1.2K
01:13Sensitivity, Specificity, and Predicted Value
1.3K
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
Sensitivity is the...
1.3K