Anatomic Site-Specific Treatment Response With 40% Hydrogen Peroxide (w/w) Topical Formulation for Raised Seborrheic...

Area of Science:

• Dermatology
• Cutaneous Oncology
• Dermatologic Surgery

Background:

• Seborrheic keratoses (SKs) are common skin growths that can appear anywhere on the body.
• Limited data exist on how SK location influences treatment outcomes.
• Understanding location-specific responses is crucial for effective treatment strategies.

Purpose of the Study:

• To investigate the relationship between the anatomic location of seborrheic keratoses (SKs) and their response to 40% (w/w) hydrogen peroxide topical solution (HP40).
• To evaluate clearance rates and local skin reactions based on SK location (face, trunk, extremities).

Main Methods:

• A pooled analysis of two randomized, double-blind, vehicle-controlled trials involving 937 patients and 3,748 SKs.
• SKs were treated with HP40 or vehicle (VEH) up to two times, with assessments at specific intervals.
• Treatment response was defined as clear or near-clear lesions using the Physician's Lesion Assessment (PLA) scale.

Main Results:

• HP40 demonstrated superior efficacy compared to VEH across all locations.
• Clearance rates were highest for facial SKs (65%) followed by truncal (46%) and extremity SKs (38%).
• Facial SKs achieved higher clearance after a single treatment, and lower rates of dyspigmentation were observed on the face.

Conclusions:

• The anatomic location of SKs significantly impacts treatment response and the risk of dyspigmentation with HP40.
• Facial SKs exhibit the best treatment outcomes and lowest risk of adverse effects.
• HP40 is an effective treatment for SKs, with location being a key factor in predicting success.