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Updated: Feb 3, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Angioimmunoblastic T-cell lymphoma mimicking diffuse large B-cell lymphoma
Carolyn Ellis1, James Ramirez2, Ann A LaFond1
1Department of Dermatology, Saint Joseph Mercy Hospital, Ann Arbor, Michigan, USA.
Abstract:
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive form of peripheral T-cell lymphoma that is characterized by lymphadenopathy, night sweats, fever, weight loss, and autoimmune phenomena. Cutaneous manifestations are present in up to 50% of cases, but few cases are reported in the dermatologic literature. We present a case of AITL that manifested in the skin. The patient was diagnosed with diffuse large B-cell non-Hodgkin lymphoma 3 months prior based on results from a lymph node biopsy. Reexamination and immunohistochemical staining of the previously biopsied lymph node specimen revealed the same clonal population of T cells positive for CD3, CD4, CD10, and programmed cell death protein 1 (PD-1) that was present in the skin and confirmed a diagnosis of AITL. Angioimmunoblastic T-cell lymphoma is frequently misdiagnosed due to its nonspecific clinical and histologic findings; it is not uncommon for AITL to be mistaken for other types of lymphoma. Dermatologists and dermatopathologists can play an important role in the recognition of this difficult-to-diagnose malignancy.
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