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Updated: Feb 3, 2026
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
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Angioimmunoblastic T-cell lymphoma mimicking diffuse large B-cell lymphoma
Carolyn Ellis1, James Ramirez2, Ann A LaFond1
1Department of Dermatology, Saint Joseph Mercy Hospital, Ann Arbor, Michigan, USA.
Cutis
|October 30, 2018
Summary
Angioimmunoblastic T-cell lymphoma (AITL) can present with skin manifestations, often leading to misdiagnosis. Early recognition by dermatologists is crucial for accurate diagnosis and treatment of this aggressive lymphoma.
Area of Science:
- Oncology
- Dermatology
- Immunology
Background:
- Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive peripheral T-cell lymphoma.
- It presents with systemic symptoms and autoimmune phenomena.
- Cutaneous involvement occurs in up to 50% of cases but is underreported in dermatologic literature.
Observation:
- A case of AITL presenting with skin manifestations is described.
- The patient was initially misdiagnosed with diffuse large B-cell non-Hodgkin lymphoma.
- Re-examination of lymph node biopsy with immunohistochemistry confirmed AITL.
Findings:
- The neoplastic T cells were positive for CD3, CD4, CD10, and programmed cell death protein 1 (PD-1).
- These findings were consistent between the skin lesions and the lymph node biopsy.
- The case highlights the diagnostic challenge posed by AITL's nonspecific features.
Implications:
- Dermatologists and dermatopathologists play a key role in identifying AITL.
- Increased awareness can improve the diagnosis of this challenging lymphoma.
- Accurate diagnosis is essential for appropriate patient management and treatment.
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