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Updated: Feb 3, 2026

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
Published on: December 1, 2023
Computational Methods for Analysis of Tumor Clonality and Evolutionary History
Gerald Goh1,2, Nicholas McGranahan3, Gareth A Wilson3,4
1Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. gohswg@gis.a-star.edu.sg.
Abstract:
Cancer is an evolutionary process. Recent advances in sequencing technologies have allowed us to investigate intratumor heterogeneity at the single nucleotide level. Here, we describe computational methods that use sequencing data to identify genetically distinct tumor subclones and reconstruct tumor evolutionary histories.
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