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Secondary hypertension in patients with saccular intracranial aneurysm disease: A population based study

Satu Kotikoski1, Jukka Huttunen1, Terhi J Huttunen1

  • 1Neurosurgery of NeuroCenter, Kuopio University Hospital, and Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Plos One
|November 1, 2018
PubMed

Insights

Secondary hypertension affects 10% of saccular intracranial aneurysm patients. It is linked to more aneurysms and male gender in subarachnoid hemorrhage cases, warranting further investigation.

Area of Science:

  • Neurology
  • Nephrology
  • Endocrinology

Background:

  • Secondary hypertension is a significant condition affecting 5-10% of hypertensive individuals.
  • Hypertension is a known risk factor for saccular intracranial aneurysms (sIA) and subarachnoid hemorrhage (aSAH).
  • The specific impact of secondary hypertension on sIA disease remains under-explored.

Purpose of the Study:

  • To determine the prevalence of secondary hypertension in a saccular intracranial aneurysm (sIA) patient cohort.
  • To investigate the association between secondary hypertension and the clinical characteristics of sIA disease, particularly subarachnoid hemorrhage (aSAH).

Main Methods:

  • A cohort of 2704 sIA patients was analyzed using data from nationwide registries and hospital records.
  • Secondary hypertension was confirmed by reviewing medical records of hypertensive sIA patients.
  • Logistic regression models were employed to identify factors associated with secondary hypertension in sIA and aSAH patients.

Main Results:

  • 10% of hypertensive sIA patients (208/2029) had secondary hypertension, commonly linked to kidney disease, sleep apnea, and hypothyroidism.
  • In patients with subarachnoid hemorrhage (aSAH), secondary hypertension was significantly associated with a higher number of sIAs (OR 1.32) and male gender (OR 1.59).

Conclusions:

  • Secondary hypertension is prevalent in hypertensive sIA patients and should be considered in their management.
  • In aSAH patients, secondary hypertension is linked to more complex disease phenotypes, including multiple aneurysms.
  • Further research is needed to understand the long-term effects of secondary hypertension on aneurysm rupture risk and patient outcomes.
Abstract

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