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Related Experiment Video

Updated: Feb 3, 2026

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
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Crystal Structure of a Tetrameric DNA Fold-Back Quadruplex.

Betty Chu1, Daoning Zhang1, Wonseok Hwang1

  • 1Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization , University of Maryland , College Park , Maryland 20742 , United States.

Journal of the American Chemical Society
|November 3, 2018
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Summary

Researchers discovered a novel DNA fold-back structure, distinct from G-quadruplexes. This unique tetrameric assembly, stabilized by cations and noncanonical base pairing, reveals new DNA structural possibilities.

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Area of Science:

  • Molecular Biology
  • Structural Biology
  • Biochemistry

Background:

  • DNA exhibits diverse structures beyond the canonical Watson-Crick duplex.
  • Understanding the full spectrum of DNA structures and their biological roles is an ongoing challenge.

Purpose of the Study:

  • To elucidate the crystal structure of a novel DNA fold-back structure.
  • To investigate the formation and characteristics of this non-G-quadruplex DNA assembly.

Main Methods:

  • X-ray crystallography at 1.05 Å resolution.
  • Analysis of DNA oligonucleotide self-association and structural assembly.

Main Results:

  • A novel DNA fold-back structure was determined, forming a tetrameric assembly from two fold-back dimers.
  • The assembly involves noncanonical and Watson-Crick interactions, including a hexad base pairing arrangement from C-G-G base triples.
  • Divalent cations are essential for assembly, forming a cation-binding cavity within the tetramer.

Conclusions:

  • This study reveals new sequence and structural contexts for fold-back quadruplex formation.
  • The findings highlight the biological significance of noncanonical DNA structures.
  • The described structure offers potential for designing DNA nanoarchitectures and cation sensors.