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Related Experiment Video

Updated: Feb 3, 2026

Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy

Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy

Published on: August 28, 2011

Tissue Mechanical Forces and Evolutionary Developmental Changes Act Through Space and Time to Shape Tooth Morphology

Zachary T Calamari^1,2, Jimmy Kuang-Hsien Hu², Ophir D Klein^2,3

¹Department of Natural Sciences, Baruch College, City University of New York, New York City, NY 10010, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology

|November 3, 2018

Summary

Evolutionary and biomechanical studies reveal common genes control tooth formation. Signaling and tissue forces shape specialized dentitions and maintain dental stem cells.

Keywords:

evolution mechanical forces morphogenesis non-model organisms progenitor cells stem cells teeth

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Area of Science:

Evolutionary Biology
Biomechanics
Developmental Biology

Background:

Tooth formation involves complex genetic, signaling, and mechanical processes.
Fossil and non-model organism studies highlight conserved genes in epithelial tooth development.
Phenotypic adaptations in dentitions are driven by changes in signaling environments.

Purpose of the Study:

To review recent advances in understanding dental development.
To discuss the roles of evolutionary and biomechanical approaches.
To identify gaps in current knowledge for future research.

Main Methods:

Integration of evolutionary studies and biomechanical experiments.
Analysis of genetic and signaling pathways in tooth development.
Examination of tissue forces and skeletal constraints during development.

Main Results:

A common genetic toolkit underlies tooth-forming potential across species.
Signaling environments and tissue forces act in parallel to shape teeth.
Specialized dentitions and stem cell maintenance are influenced by these factors.

Conclusions:

Evolutionary and biomechanical approaches provide crucial insights into dental development.
Continued research is needed to fill knowledge gaps in tooth formation and function.
Understanding these processes is key to addressing dental adaptations and diseases.