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Influenza update 2018-2019: 100 years after the great pandemic
1Department of Infectious Diseases, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA. mossads@ccf.org.
Cleveland Clinic Journal of Medicine
|November 6, 2018
Summary
Annual influenza vaccination is crucial for preventing pandemics. New antiviral drugs like baloxavir marboxil offer additional strategies against influenza.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Influenza pandemics have caused significant global mortality since 1918.
- Yearly vaccination is recommended for individuals aged 6 months and older.
- Vaccination targets include 80% of Americans and 90% of at-risk groups.
Observation:
- Current influenza prevention relies heavily on vaccination.
- Neuraminidase inhibitors, a class of antiviral drugs, are underutilized.
- A novel antiviral, baloxavir marboxil, with a distinct mechanism, is nearing US approval.
Findings:
- Despite vaccination efforts, influenza remains a global health concern.
- Underuse of neuraminidase inhibitors represents a gap in influenza treatment.
- The introduction of baloxavir marboxil signifies a potential advancement in influenza pharmacotherapy.
Implications:
- Enhanced vaccination coverage is essential for pandemic preparedness.
- Optimizing the use of existing antivirals and adopting new ones can improve influenza management.
- Baloxavir marboxil's approval may offer a new therapeutic option for influenza treatment.
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