Related Experiment Video
Updated: Feb 3, 2026

Imaging Centrosomes in Fly Testes
Published on: September 20, 2013
A centrosomal view of CNS growth
Murielle Saade1, Jose Blanco-Ameijeiras2, Elena Gonzalez-Gobartt2
1Department of Developmental Biology, Instituto de Biología Molecular de Barcelona, Parc Científic de Barcelona, Baldiri i Reixac 20, Barcelona 08028, Spain msabmc@ibmb.csic.es.
Abstract:
Embryonic development of the central nervous system (CNS) requires the proliferation of neural progenitor cells to be tightly regulated, allowing the formation of an organ with the right size and shape. This includes regulation of both the spatial distribution of mitosis and the mode of cell division. The centrosome, which is the main microtubule-organizing centre of animal cells, contributes to both of these processes. Here, we discuss the impact that centrosome-mediated control of cell division has on the shape of the overall growing CNS. We also review the intrinsic properties of the centrosome, both in terms of its molecular composition and its signalling capabilities, and discuss the fascinating notion that intrinsic centrosomal asymmetries in dividing neural progenitor cells are instructive for neurogenesis. Finally, we discuss the genetic links between centrosome dysfunction during development and the aetiology of microcephaly.
Related Concept Videos
Centrioles and Centrosomes
Near the end of the prophase, also called late prophase or...
Centrosome Duplication
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
Econometric Views (EViews)
Cranial Bones: Lateral View
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
CNS Depressants: Alcohol and Nicotine
CNS Depressants: Barbiturates and Benzodiazepines

