[Interaction between microbiota and immune system in colorectal cancer]

Area of Science:

• Oncology
• Microbiology
• Immunology

Background:

• Growing evidence links colorectal microbiota and immune system interactions to colorectal cancer (CRC) progression.
• These interactions also influence treatment efficacy in CRC patients.

Purpose of the Study:

• To review current knowledge on the role of the gut microbiota in colorectal cancer.
• To explore how microbiota modulation can be used for CRC prevention and treatment.

Main Methods:

• Literature review of in vivo and in vitro studies.
• Synthesis of current research on bacterial drivers, biofilm formation, and CRC sidedness.
• Analysis of oncological treatments, including immunotherapy.

Main Results:

• The interplay between gut bacteria and the immune system is crucial for CRC development.
• Microbiota composition and biofilm formation are key factors in CRC.
• Understanding CRC sidedness and treatment responses is enhanced by considering microbiota.

Conclusions:

• Modulating the gut microbiota and immune system presents a promising avenue for CRC prevention and treatment.
• Future CRC strategies will likely incorporate microbiome-targeted therapies and immunotherapies like checkpoint inhibitors.