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Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
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Towards Closed-Loop Neuromodulation: A Wireless Miniaturized Neural Implant SoC
Wentai Liu1, Po-Min Wang1, Yi-Kai Lo1
1University of California, Los Angeles, Los Angeles, CA, USA 90095.
Proceedings of Spie--The International Society for Optical Engineering
|November 10, 2018
Summary
This study introduces a new platform for closed-loop neuromodulation systems. It demonstrates potential for treating spinal cord injuries and other biomedical applications.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Implantable Devices
Background:
- Developing effective closed-loop neuromodulation systems is crucial for advanced therapies.
- Existing systems often lack the integrated functionality required for complex biomedical applications.
Purpose of the Study:
- To report a platform technology for developing closed-loop neuromodulation.
- To illustrate essential functionalities for efficacious implantable neuromodulation systems.
- To demonstrate the system's application in spinal cord injury research.
Main Methods:
- Development of a neural implant based on a System-on-Chip (SoC).
- Hardware-software co-design approach for integrated system development.
- Utilizing the system for epidural stimulation in a rat model of spinal cord injury.
Main Results:
- The platform technology enables the development of functional closed-loop neuromodulation systems.
- The neural implant demonstrated necessary functionalities for an efficacious system.
- Successful investigation of epidural stimulation for motor function recovery in a rat model.
Conclusions:
- The presented hardware-software co-design tool shows significant promise for closed-loop neuromodulation.
- This technology can be applied to various biomedical applications, including spinal cord injury treatment.
- The platform facilitates the development of effective and efficacious implantable neuromodulation solutions.
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