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SILAC Based Proteomic Characterization of Exosomes from HIV-1 Infected Cells
Published on: March 3, 2017
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Exosome Biogenesis and Biological Function in Response to Viral Infections.
Brennetta J Crenshaw1, Linlin Gu2, Brian Sims3
1Department of Biological Sciences, Microbiology Program, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL, USA.
The Open Virology Journal
|November 13, 2018
Summary
Exosomes, tiny vesicles involved in cell communication, play a critical role in viral infections by influencing host responses and immunity. This review explores exosome biogenesis, composition, and therapeutic potential in viral pathogenesis.
Area of Science:
- Cell Biology
- Virology
- Immunology
Background:
- Exosomes are extracellular vesicles involved in intercellular communication, transferring proteins, lipids, and RNAs.
- Exosomes and viruses share structural and molecular similarities, suggesting a complex interplay.
- The role of exosomes in viral infections is an emerging area of research.
Purpose of the Study:
- To review the impact of exosome biogenesis and composition during DNA, RNA, and retroviral infections.
- To explore the potential of exosomes as therapeutic agents and vaccine vehicles.
Main Methods:
- Literature review of studies on exosome biogenesis and viral infections.
- Analysis of exosome-host-pathogen interactions.
- Evaluation of exosome-based therapeutic strategies.
Main Results:
- Viral hijacking of the exosomal pathway influences host cell responses.
- Exosomes from infected cells carry viral and host factors, modulating pathogenesis.
- Exosomes can activate antiviral mechanisms and facilitate intercellular antiviral factor transport.
Conclusions:
- Exosomes are integral to viral pathogenesis and host antiviral responses.
- Understanding exosome dynamics in infection is crucial for developing novel therapies.
- Exosomes hold promise as therapeutic agents and vaccine delivery systems.
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