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Contrast-Enhanced Subharmonic Aided Pressure Estimation SHAPE Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension
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On Factors Affecting Subharmonic-aided Pressure Estimation (SHAPE).

Ipshita Gupta1,2, John R Eisenbrey1, Priscilla Machado1

  • 11 Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.

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|November 13, 2018
PubMed
Summary
This summary is machine-generated.

Subharmonic-aided pressure estimation (SHAPE) accurately measures hydrostatic pressure. An improved algorithm enhances SHAPE

Keywords:
acoustic powercontrast agent concentrationhematocritoptimizationsubharmonic imagingsubharmonic pressure estimationultrasound

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Area of Science:

  • Medical Imaging
  • Ultrasound Technology
  • Biomedical Engineering

Background:

  • Subharmonic-aided pressure estimation (SHAPE) leverages ultrasound contrast agents (UCAs) to measure hydrostatic pressure.
  • Understanding the factors influencing SHAPE accuracy is crucial for its clinical application.

Purpose of the Study:

  • To investigate the impact of incident acoustic output (IAO), UCA concentration, and hematocrit on SHAPE accuracy.
  • To evaluate an improved IAO selection algorithm for SHAPE.

Main Methods:

  • Utilized a Logiq 9 scanner with a 4C curvilinear probe and Sonazoid UCAs.
  • Varied IAO, UCA concentration (0.2-1.2 mL/L), and hematocrit (1.8-4.5 mL/L).
  • Analyzed SHAPE gradient correlations with pressure, hematocrit, and UCA concentration in 100 patients.

Main Results:

  • An improved IAO selection algorithm significantly enhanced correlation coefficients (r from -0.85 to -0.95).
  • SHAPE gradient remained stable across pressures (10-40 mmHg).
  • No significant changes in SHAPE gradient were observed with increased hematocrit or UCA concentration (p > 0.18).

Conclusions:

  • SHAPE is independent of hematocrit and UCA concentration, indicating robustness.
  • An optimized IAO selection algorithm is key to improving SHAPE accuracy.
  • SHAPE shows potential for accurate hydrostatic pressure estimation in clinical settings.