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Copper-catalyzed oxidative intermolecular 1,2-alkylarylation of styrenes with ethers and indoles
Rongkui Su1, Yang Li2, Man-Yi Min2
1Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang 330063, China. xuanhuiouyang@163.com srj0731@hnu.edu.cn jhli@hnu.edu.cn and School of Metallurgy and Environment, Central South University, National Engineering Research Center for Control & Treatment of Heavy Metal Pollution, Changsha, 410083, China.
Abstract:
A new copper-catalyzed oxidative three-component intermolecular 1,2-alkylarylation of styrenes with ethers and indoles is disclosed. This method utilizes TBPB as an oxidant to efficiently construct C(sp3)-C(sp3) and C(sp3)-C(sp2) bonds in one step through probable radical and electrophilic alkylation processes, respectively, and a variety of functional groups are well tolerated.
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