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Updated: Feb 2, 2026

Inhibition of Wound Epidermis Formation via Full Skin Flap Surgery During Axolotl Limb Regeneration
Published on: June 24, 2020
Neuromuscular electrostimulation on lower limb wounds.
Nia J Jones1, Nicola Ivins2, Vicky Ebdon3
1Research Podiatrist and Honorary Tutor in Wound Healing, Welsh Wound Innovation Centre, Cardiff.
The geko™ neuromuscular electrostimulation (NMES) device showed potential in improving chronic lower limb wounds. While complete healing was limited, it reduced wound size and increased granulation tissue, benefiting patients with painful leg ulcers.
Area of Science:
- Biomedical Engineering
- Wound Healing Research
- Clinical Case Series
Background:
- Chronic lower limb wounds, including venous leg ulceration (VLU), mixed leg ulceration (MLU), and diabetic foot ulceration, present a significant clinical challenge.
- The geko™ device is a disposable neuromuscular electrostimulation (NMES) system designed to enhance blood circulation and promote wound healing.
- Evaluating novel therapeutic interventions is crucial for improving outcomes in patients with non-healing wounds.
Purpose of the Study:
- To assess the therapeutic efficacy of the geko™ NMES device on wound healing outcomes.
- To evaluate changes in wound surface area, granulation tissue, pain, and oedema over an 8-week period.
- To explore the potential benefits of NMES in managing chronic lower limb conditions.
Main Methods:
- A case series involving 30 patients with non-healing lower limb wounds (duration ≥ 12 weeks) was conducted.
- Participants received treatment with the geko™ device over an 8-week period.
- Wound assessments included surface area, tissue composition, pain levels, and oedema, with consideration for standard care interventions like compression therapy.
Main Results:
- Complete re-epithelialisation was achieved in 8% of participants.
- A mean decrease in wound surface area of 7.6 cm² was observed.
- A 21% increase in mean granulation tissue percentage and pain reduction in 52% of patients were noted.
Conclusions:
- The geko™ NMES device shows promise in improving wound healing parameters, particularly in patients with painful VLUs and MLUs.
- Observed reductions in wound size and pain suggest a potential benefit for NMES therapy.
- Further research is warranted to confirm generalisability across diverse chronic wound aetiologies and patient populations.
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