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Evolving Role of PET/CT-MRI in Assessing Muscle Disorders

Esha Kothekar1, William Y Raynor2, Abdullah Al-Zaghal1

  • 1Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.

PET Clinics
|November 14, 2018
PubMed

Insights

Proper patient preparation minimizes variability in 2-Deoxy-2-[18F]fluoroglucose (FDG) muscle uptake, improving the detection of pathology. This enhances the diagnostic utility of FDG-PET/CT for both malignant and potentially inflammatory conditions.

Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiology

Background:

  • 2-Deoxy-2-[18F]fluoroglucose (FDG) uptake in skeletal muscle is affected by physiological processes and pathology.
  • Variability in FDG uptake can obscure or mimic abnormal findings on PET/CT scans.

Purpose of the Study:

  • To highlight the importance of patient preparation in standardizing FDG muscle uptake.
  • To discuss the established and potential applications of FDG-PET/CT in evaluating muscle abnormalities.

Main Methods:

  • Review of physiological factors influencing FDG muscle uptake.
  • Analysis of FDG-PET/CT imaging in malignant and inflammatory muscle conditions.

Main Results:

  • Standardized patient preparation can significantly reduce physiological variability in muscle FDG uptake.
  • FDG-PET/CT is effective in diagnosing malignant muscle diseases like rhabdomyosarcoma and metastasis.
  • Potential for FDG-PET/CT in diagnosing infections and benign inflammatory muscle disorders requires further investigation.

Conclusions:

  • Optimizing patient preparation is crucial for accurate interpretation of FDG muscle uptake in PET/CT.
  • FDG-PET/CT has established roles in oncology and emerging potential in infectious and inflammatory myopathies.
Keywords:
FDGInflammatory muscle disordersMuscle disordersMusculoskeletal malignanciesPET/CT-MRI

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