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Fluorescent Nanodiamond Applications for Cellular Process Sensing and Cell Tracking.

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Fluorescent nanodiamonds (FND) are biocompatible probes for tracking cellular processes and biodistribution. Their unique properties enable high-resolution intracellular analysis and cell tracking in oncology and regenerative medicine.

Keywords:
bioimagingbiosensingnanodiamondnitrogen-vacancy defectssingle particle tracking

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Area of Science:

  • Nanotechnology
  • Biophysics
  • Materials Science

Background:

  • Nanodiamonds (<100 nm) exhibit high biocompatibility.
  • Nitrogen-vacancy (NV) color centers impart fluorescence and photostability to nanodiamonds, creating fluorescent nanodiamonds (FND).
  • FND have served as fluorescent probes for biological analysis since the late 2000s.

Purpose of the Study:

  • To review FND applications in sensing molecular processes and tracking biological entities.
  • To explore biosensing potential using NV center electron spin resonance.
  • To highlight FND utility in biodistribution studies and cell tracking for medical applications.

Main Methods:

  • Utilizing sub-diffraction sized FND for high spatio-temporal resolution intracellular tracking.
  • Employing FND for monitoring therapeutic compound and cell fate in vivo.
  • Leveraging optically detectable electron spin resonance of NV- centers for biosensing.

Main Results:

  • FND enable precise tracking of intra- and intercellular molecular processes.
  • FND serve as effective probes for determining biodistribution of nanoparticles.
  • FND facilitate cell tracking for diagnostic and follow-up purposes in oncology and regenerative medicine.

Conclusions:

  • FND are versatile tools for advanced biological imaging and sensing.
  • The biocompatibility and unique optical properties of FND offer significant potential in biomedical research.
  • FND applications span from fundamental cell biology to clinical diagnostics and therapeutic monitoring.