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Preparation and Friction Force Microscopy Measurements of Immiscible, Opposing Polymer Brushes

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Acoustofluidic Measurements on Polymer-Coated Microbubbles: Primary and Secondary Bjerknes Forces.

Gianluca Memoli^1,2, Kate O Baxter³, Helen G Jones⁴

¹School of Engineering and Informatics, University of Sussex, BN1 9QJ Falmer, UK. g.memoli@sussex.ac.uk.

|November 15, 2018

Summary

This study reveals the buckling pressure threshold for coated microbubbles in acoustofluidics. Understanding this critical parameter is vital for accurate microbubble manipulation in diagnostics and drug delivery.

Keywords:

Bjerknes forces acoustofluidics compressibility microbubbles

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Area of Science:

Acoustofluidics
Microfluidics
Biophysics

Background:

Acoustically-driven dynamics of particles in microfluidics are well-studied.
Coated microbubbles, crucial for diagnostics and therapeutics, have poorly characterized acoustically-driven behavior due to their compressibility and strong Bjerknes forces.

Purpose of the Study:

To investigate the translational dynamics of polymer-coated microbubbles in a standing-wave acoustofluidic device.
To quantify acoustic forces, bubble-bubble interactions, and aggregation phenomena.
To characterize microbubble compressibility and identify the buckling pressure threshold.

Main Methods:

Utilized a standing-wave acoustofluidic device to study commercially-available polymer-coated microbubbles.
Measured acoustic forces on isolated bubbles and bubble-bubble interaction forces during doublet formation.
Employed scanning electron microscopy for benchmarking and determining the buckling onset.

Main Results:

Presented a dynamic characterization of microbubble compressibility as a function of acoustic pressure.
Identified a threshold pressure below which coated microbubbles behave like uncoated ones, interpreted as the onset of buckling.
Quantified the single-bubble buckling pressure.

Conclusions:

Microbubbles cannot be treated as a simple case of solid particles in acoustofluidic applications.
The identified buckling pressure is a critical parameter impacting microbubble behavior in diagnostics and drug delivery.