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Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
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LED Optrode with Integrated Temperature Sensing for Optogenetics.

S Beatriz Goncalves1,2, José M Palha3, Helena C Fernandes4

  • 1Institute of Applied Micro-Nano Science and Technology-IAMNST, Chongqing Key Laboratory of Colleges and Universities on Micro-Nano Systems Technology and Smart Transducing, Chongqing Engineering Laboratory for Detection, Control and Integrated System, National Research Base of Intelligent Manufacturing Service, Chongqing Technology and Business University, Nan'an District, Chongqing 400067, China. sgoncalves@dei.uminho.pt.

Micromachines
|November 15, 2018
PubMed

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Summary
This summary is machine-generated.

This study introduces a novel neural tool for optogenetics, integrating electrical recording, optical stimulation, and real-time temperature monitoring to prevent overheating and cell damage during brain research.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Optogenetics

Background:

  • Optogenetic studies risk cell damage from overheating due to high-power light sources.
  • Inadequate power density or exposure time can lead to detrimental temperature increases in neural tissue.

Purpose of the Study:

  • To develop a neural tool for simultaneous electrical recording, optical stimulation, and tissue temperature assessment.
  • To mitigate overheating issues in optogenetics by providing real-time thermal monitoring.

Main Methods:

  • A silicon-based, 8 mm long probe was fabricated with an optrode (LED stimulation, Pt recording points) and a platinum (Pt) thin-film resistance temperature detector (RTD).
  • The RTD was designed for precise temperature assessment near the photostimulation site.
  • The probe's design facilitates integration into 3D probe arrays for reduced sensor-to-source distance.
Keywords:
LED chipoptogeneticssilicon neural probestemperature monitoringthermoresistance

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Main Results:

  • The device demonstrated effective recording and optical stimulation capabilities, with an average impedance magnitude of 371 kΩ at 1 kHz and optical power of 1.2 mW·mm⁻² (470 nm).
  • The manufactured RTD achieved a resolution of 0.2°C at 37°C, ensuring accurate temperature monitoring.
  • Pt thin-films were utilized for their biocompatibility and thermal linearity.

Conclusions:

  • The developed neural tool successfully meets the requirements for neural interface applications, enabling simultaneous recording, stimulation, and temperature monitoring.
  • This device offers a promising solution for enhancing the safety and efficacy of optogenetics in neuroscience research.
  • The integration into 3D probe arrays further enhances its utility for deep neural structure investigations.