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Using the Patient-Reported Outcomes Measurement Information System (PROMIS) to measure symptom burden reported by
Jin-Shei Lai1,2, Mary Jo Kupst3, Jennifer L Beaumont1,4
1Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Pediatric Blood & Cancer
|November 15, 2018
Summary
Children with brain tumors experience significant symptom burden. Patient-Reported Outcomes Measurement Information System (PROMIS) tools effectively assess these symptoms and associated factors in pediatric patients.
Area of Science:
- Pediatric Oncology
- Clinical Psychology
- Health Outcomes Research
Background:
- Children diagnosed with brain tumors face a substantial symptom burden throughout their illness.
- Understanding this symptom burden and its associated factors is crucial for improving patient care.
Purpose of the Study:
- To evaluate the symptom burden experienced by children with brain tumors.
- To identify factors associated with these symptoms in pediatric brain tumor patients.
Main Methods:
- Analyzed data from 199 children (aged 7-22) with brain tumors.
- Assessed symptom burden using Patient-Reported Outcomes Measurement Information System (PROMIS) computerized adaptive testing (CAT) for anxiety, depression, fatigue, mobility, upper extremity function, peer relationships, and cognition.
- Utilized Symptom Distress Scales (SDS) completed by patients and parents; employed statistical tests (ANOVA) to analyze relationships.
Main Results:
- PROMIS measures strongly correlated with patient and parent-reported Symptom Distress Scales.
- Fatigue, mobility, and upper extremity function were linked to functional status, treatment modalities, and time since treatment.
- Cognition and fatigue associated with educational support needs; mobility, upper extremity function, and anxiety linked to radiation and chemotherapy timing.
Conclusions:
- Established significant associations between PROMIS measures and clinical/demographic characteristics.
- Demonstrated that brief PROMIS CATs are effective for systematic assessment of symptom burden in pediatric brain tumor patients.
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