Different distribution of ELI-perikarya in rat mesencephalon using various injection sites for colchicine

In the present work, using the indirect peroxidase-labelled antibody technique, we made a comparative study about the distribution of Met-enkephalin-like-immunoreactive (ELI)-cell bodies in rat mesencephalon; comparing animals that received colchicine into the lateral ventricle and animals that got the colchicine injected into different cerebral nuclei. We discuss the possibility that the local intracerebral injections are more effective than the intraventricular ones and we show that the results depend on the injection place. So, we think that there are possible met-enkephalinergic connections between the injected region and their corresponding immunoreactive mesencephalic nuclei.