Parry-Romberg syndrome in a patient with scleroderma

Area of Science:

• Neurology
• Dermatology
• Rheumatology

Background:

• Parry-Romberg syndrome (PRS) is a rare disorder characterized by progressive hemifacial atrophy.
• Scleroderma is an autoimmune disease causing skin and connective tissue hardening.

Observation:

• A 48-year-old woman presented with a 3-year history of worsening right facial hemiatrophy.
• She also had alopecia, hyperpigmentation, headaches, and neck stiffness.
• Her medical history included scleroderma.

Findings:

• Clinical diagnosis of Parry-Romberg syndrome was established.
• The patient received methotrexate treatment.
• Multidisciplinary follow-up with dermatology, rheumatology, and maxillofacial surgery was initiated.

Implications:

• This case underscores the importance of recognizing PRS in patients with connective tissue diseases like scleroderma.
• Early diagnosis and multidisciplinary management are crucial for optimizing outcomes.
• Reconstructive surgery is considered for symptom stabilization and functional improvement.