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Related Concept Videos

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Related Experiment Video

Updated: Feb 2, 2026

Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
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Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

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CGRP Discovery and Timeline.

Kate Arkless1, Fulye Argunhan1, Susan D Brain2

  • 1Section of Vascular Biology & Inflammation, School of Cardiovascular Medicine & Sciences, BHF Centre for Cardiovascular Sciences, King's College London, London, UK.

Handbook of Experimental Pharmacology
|November 16, 2018
PubMed
Summary
This summary is machine-generated.

Calcitonin gene-related peptide (CGRP) is a vasodilator involved in pain. CGRP blockers now benefit migraine patients, but more research is needed on CGRP

Keywords:
CGRPCardiovascularMigraineReview

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Calcitonin gene-related peptide (CGRP) discovered 35 years ago.
  • CGRP's roles as a vasodilator and in pain processing established.
  • CGRP antagonists and antibodies are approved for migraine treatment.

Purpose of the Study:

  • Review the history and current knowledge of CGRP.
  • Discuss CGRP's relevance in disease and potential applications.
  • Serve as an introductory chapter for a volume on CGRP.

Main Methods:

  • Literature review of CGRP research.
  • Analysis of clinical applications of CGRP modulators.
  • Synthesis of historical and current findings.

Main Results:

  • CGRP's established roles in vasodilation and pain.
  • Clinical success of CGRP-blocking therapies for migraine.
  • Significant knowledge gaps remain regarding CGRP's broader functions.

Conclusions:

  • CGRP is a key molecule in neuroscience and pain research.
  • CGRP-targeted therapies represent a significant advancement in migraine management.
  • Further investigation into CGRP's diverse activities and therapeutic potential is warranted.