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Polyhydroxyalkanoates as biomaterial for electrospun scaffolds.

Claudia Sanhueza1, Francisca Acevedo2, Sebastian Rocha3

  • 1Doctoral Program in Sciences of Natural Resources, Universidad de La Frontera, Casilla 54-D, Temuco, Chile.

International Journal of Biological Macromolecules
|November 17, 2018
PubMed
Summary

Polyhydroxyalkanoates (PHA) biopolymers can be electrospun into fibers to enhance their mechanical and thermal properties. This technique improves PHA suitability for tissue engineering applications.

Keywords:
Bacterial polyhydroxyalkanoatesElectrospinningFibersScaffoldsTissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Polyhydroxyalkanoates (PHA) are biodegradable polyesters with limited mechanical and thermal properties.
  • Electrospinning is a method to create polymer fibers, improving PHA characteristics.
  • PHA's potential in medical applications is hindered by its intrinsic properties.

Purpose of the Study:

  • To explore the use of electrospinning for developing Polyhydroxyalkanoates (PHA)-based scaffolds.
  • To investigate how electrospinning affects the mechanical and structural properties of PHA.
  • To enhance the applicability of PHA in tissue engineering through fiber modification.

Main Methods:

  • Electrospinning of Polyhydroxyalkanoates (PHA) and its copolymers.
  • Blending PHA with natural polymers (gelatin, zein, cellulose acetate) and synthetic polymers.
  • Coaxial electrospinning using PHA as core and gelatin as shell.
  • Incorporation of plasticizers to improve PHA miscibility.

Main Results:

  • Electrospun PHA fibers exhibit improved mechanical properties and reduced crystallinity.
  • The formation of a metastable structure (β-form) in PHA fibers contributes to property enhancement.
  • Aligned fibers show superior mechanical strength compared to randomly oriented fibers.
  • Blended PHA fibers demonstrate improved mechanical and biological performance.

Conclusions:

  • Electrospinning is a viable technique to overcome the limitations of PHA.
  • Modified PHA fibers show promise for advanced tissue engineering scaffolds.
  • Tailoring PHA fiber structure and composition enhances its potential for biomedical applications.