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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Historical Perspectives in the Evolution of Hypertrophic Cardiomyopathy

Julio A Panza1, Srihari S Naidu1

  • 1Division of Cardiology, Westchester Medical Center, New York Medical College, 100 Woods Road, Macy Pavilion, Suite 11, Valhalla, NY 10595, USA.

Cardiology Clinics
|November 19, 2018
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) research has advanced significantly since 1958. Ongoing progress in imaging and treatments offers hope for improved therapies and potential prevention of this heart condition.

Area of Science:

  • Cardiology
  • Genetics
  • Medical History

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease.
  • First described anatomically in 1958, HCM affects millions globally.
  • Understanding of HCM pathogenesis has evolved considerably.

Observation:

  • Significant advancements in diagnostic imaging techniques for HCM.
  • Development of novel therapeutic strategies and treatment modalities.
  • Longitudinal studies tracking disease progression and outcomes.

Findings:

  • Progress in HCM diagnosis and management has been substantial.
  • New imaging tools enhance visualization of cardiac structures and function.
  • Emerging treatments target specific molecular pathways.

Implications:

  • Future research aims for enhanced treatment efficacy in HCM.
  • Potential for early detection and preventative strategies.
  • Improved patient outcomes and quality of life for individuals with HCM.

Keywords:
Alcohol septal ablationGeneticsHypertrophic cardiomyopathyImplantable cardioverter-defibrillatorSeptal myectomy

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