Related Experiment Video
Updated: Feb 2, 2026

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
Published on: February 27, 2019
Relationship between Cell Receptors and Tumor Cell Sensitivity to Oncolytic Enteroviruses
A V Lipatova1, T H Le1, A O Sosnovtseva1
1V. A. Engelhardt Institute of Molecular Biology, the Russian Academy of Sciences, Moscow, Russia.
Abstract:
Replicative ability of 5 oncolytic enterovirus strains was evaluated on a panel of 18 human normal and tumor cells. The capacity of each cell line to support replication of enterovirus strains varied. Cell lines weakly replicating one virus could be highly sensitive to another viral strain. Differences in the expression of CXADR cell receptor did not correlate with susceptibility to infection and replication of Coxsackie B virus, but complete inactivation of CXADR gene and poliovirus receptor gene (PVR) led to loss of the sensitivity to Coxsackie B5 and poliovirus, respectively. Detection of additional expression markers will contribute to understanding the causes of different sensitivity of tumor cells to viruses.
Related Concept Videos
Types of Receptors: Cell Surface Receptors
Relationship Formation
Ending Relationships
Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Internal Receptors
Relationship Growth

