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Updated: Feb 2, 2026

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Published on: October 21, 2011
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Plug vs. suture: Who wins in large bore access closure?
Wassim Shatila1,2,3, Zvonimir Krajcer1,2,3
1Department of Cardiology, Texas Heart Institute, Houston, Texas.
Summary
Novel vascular closure devices offer a safe alternative to surgical closure for large bore access. The MANTA device shows promise for reduced bleeding, with potential links to genetic factors.
Area of Science:
- Cardiovascular interventions
- Vascular surgery
- Medical device technology
Background:
- Large bore vascular access is increasingly common in medical procedures.
- Surgical closure was the traditional method for managing large bore access sites.
- Minimally invasive closure devices present a safer alternative to surgical intervention.
Discussion:
- The MANTA vascular closure device provides a safe and effective option for large bore access closure.
- Compared to surgical closure, the MANTA device is associated with significantly less bleeding.
- The study explores potential genetic influences, such as specific polymorphisms, that may contribute to Hemostatic ত্বক Perfusion (HoTPR).
Key Insights:
- The MANTA device offers a less invasive approach to vascular closure.
- Reduced bleeding complications are a key advantage of the MANTA device.
- Investigating genetic factors like polymorphisms may elucidate individual variability in hemostasis.
Outlook:
- Further research into genetic polymorphisms could personalize vascular closure strategies.
- The MANTA device represents a significant advancement in minimally invasive vascular closure techniques.
- Continued evaluation of long-term outcomes and safety profiles for novel closure devices is warranted.
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