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Updated: Feb 2, 2026

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
Published on: September 16, 2022
[Liquid biopsy: a possible approach for cancer screening]
1IRCM, Institut de recherche en cancérologie de Montpellier, 208, avenue des Apothicaires, Montpellier, F-34298, France - Inserm U1194, Montpellier, F-34298, France - Université de Montpellier, Montpellier, F-34090, France - Institut régional du cancer de Montpellier, Montpellier, F-34298, France.
Liquid biopsy shows potential for early cancer detection using circulating biomarkers. While no universal screening test exists yet, advanced multi-parametric methods are improving its credibility for cancer diagnostics.
Area of Science:
- Oncology
- Molecular Diagnostics
- Biomarker Discovery
Background:
- Liquid biopsy offers a noninvasive approach for cancer screening and monitoring.
- Circulating biomarkers like cell-free DNA, circulating tumor cells, and microRNAs are being investigated.
- Early cancer detection is crucial for reducing mortality and improving patient survival rates.
Purpose of the Study:
- To review studies on liquid biopsy for developing cancer screening and early detection tests.
- To assess the current status and future potential of liquid biopsy in oncology.
Main Methods:
- Analysis of existing literature on liquid biopsy biomarkers for cancer screening.
- Evaluation of studies focusing on circulating DNA, circulating tumor cells, and microRNAs.
- Assessment of multi-parametric approaches in liquid biopsy analysis.
Main Results:
- No liquid biopsy test is currently specific and sensitive enough for universal cancer screening.
- Various circulating biomarkers show promise for theranostics and patient monitoring.
- Sophisticated multi-parametric methods are enhancing the capabilities of liquid biopsy.
Conclusions:
- Liquid biopsy holds significant promise as a tool for cancer screening and early detection.
- Further advancements in multi-parametric analysis are key to realizing the full potential of liquid biopsy.
- Continued research is essential to develop clinically validated, highly specific, and sensitive liquid biopsy-based screening tests.
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08:49Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
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