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Constituents from Entada scandens with TRAIL-resistance Overcoming Activity

Firoj Ahmed, Kazufumi Toume, Naoki Ishikawa

    Natural Product Communications
    |November 20, 2018
    PubMed

    Insights

    Researchers explored natural products to overcome cancer therapy resistance. Compounds from Entada scandens showed moderate activity in overcoming tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) resistance in gastric cancer cells.

    Area of Science:

    • Natural Product Chemistry
    • Cancer Biology
    • Pharmacology

    Background:

    • Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent due to its selective tumor cell-killing ability.
    • TRAIL resistance significantly hinders its therapeutic efficacy, necessitating the discovery of novel compounds to overcome this challenge.
    • Natural products represent a valuable source for identifying bioactive compounds with potential anticancer properties.

    Purpose of the Study:

    • To identify natural products capable of overcoming TRAIL resistance in cancer therapy.
    • To investigate the TRAIL-resistance overcoming activity of compounds isolated from Entada scandens.

    Main Methods:

    • Bioassay-guided fractionation of the plant extract Entada scandens.
    • Isolation and characterization of four compounds from the plant.
    • Evaluation of the isolated compounds' activity in overcoming TRAIL resistance using TRAIL-resistant human gastric adenocarcinoma (AGS) cells.

    Main Results:

    • Four compounds (1-4) were isolated from Entada scandens.
    • Compounds 1 and 3 demonstrated moderate activity in overcoming TRAIL resistance.
    • The activity was observed in TRAIL-resistant human gastric adenocarcinoma (AGS) cells.

    Conclusions:

    • Entada scandens is a source of compounds with TRAIL-resistance overcoming potential.
    • Compounds 1 and 3 show promise as lead compounds for developing strategies to enhance TRAIL-based cancer therapy.
    • Further research is warranted to explore the mechanisms and optimize the efficacy of these compounds.

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