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Tertiary Lymphoid Structures in Colorectal Cancers and Their Prognostic Value
Gjorgji Trajkovski1, Ljubomir Ognjenovic1, Zoran Karadzov1
1University Clinic of Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje, Republic of Macedonia.
Open Access Macedonian Journal of Medical Sciences
|November 21, 2018
Summary
Tertiary lymphoid structures (TLS) density is higher in patients with less advanced colorectal cancer (CRC). Higher TLS density correlates with better tumor differentiation and indicates a role in controlling tumor progression.
Area of Science:
- Immunology
- Oncology
- Pathology
Background:
- Tumor-infiltrating lymphocytes (TILs) are crucial for anti-tumor immunity.
- Tertiary lymphoid structures (TLS), formed by B lymphocytes, are observed in various solid tumors, including colorectal carcinoma (CRC).
- TLS influence local and systemic anti-cancer responses.
Purpose of the Study:
- Quantify TLS presence in CRC patients.
- Determine the role of TLS in colorectal cancer progression.
Main Methods:
- Analysis of surgical specimens from 103 CRC patients.
- Determination of TLS density.
- Correlation of TLS density with tumor stage, lymph node status, lymphatic invasion, and tumor grade.
Main Results:
- Higher TLS density was observed in patients with higher disease stage, lower T status, and negative lymph nodes.
- Absence of lymphatic invasion and better tumor differentiation were associated with increased TLS density.
- TLS density showed a significant correlation with these prognostic factors.
Conclusions:
- TLS density is a significant factor in controlling tumor growth in CRC.
- TLS density can serve as a prognostic parameter for neoplasm progression in colorectal cancer patients.
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