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Updated: Feb 2, 2026

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
Published on: August 17, 2018
Noninvasive brain stimulation over dorsolateral prefrontal cortex for pain perception and executive function in aging
JaeHyuk Lee1, Yan Jin1, SeJun Oh2
1Major in Rehabilitation Science, Graduate School, Korea University, Seoul, South Korea; Department of Physical Therapy, College of Health Science, Korea University, Seoul, South Korea.
This study shows transcranial direct current stimulation (tDCS) is feasible for improving pain perception in older adults. Further research is needed to explore its effects on executive function.
Area of Science:
- Neuroscience
- Gerontology
- Rehabilitation Medicine
Background:
- Aging affects the dorsolateral prefrontal cortex (DLPFC), impacting cognitive functions and pain perception.
- Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that modulates cortical excitability.
Purpose of the Study:
- To assess the feasibility of using tDCS to improve pain perception and executive function in community-dwelling elderly individuals.
- To investigate the effects of different tDCS intensities (1mA and 2mA) and sham stimulation on aging-related outcomes.
Main Methods:
- A double-blind, single-arm trial with a sham period was conducted.
- Twenty-four elderly participants received 5 consecutive daily sessions of anodal tDCS over the DLPFC for 20 minutes.
- Pain perception was evaluated using the Visual Analogue Scale, Pain Self-Efficacy Scale, Tampa Scale for Kinesiophobia, and Global Perceived Effect Scale.
- Executive function was assessed using the Trail Making Test and Timed Up and Go test.
- Maximal grip strength and the 12-item Short Form Survey were secondary outcome measures.
Main Results:
- Significant improvements were observed in pain perception and quality of life following tDCS.
- No significant changes were detected in executive function or maximal grip strength.
Conclusions:
- tDCS is a feasible intervention for managing aging-related pain perception in the elderly.
- Further randomized controlled trials with extended durations are warranted to fully evaluate tDCS effects on executive function in this population.
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