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Updated: Feb 2, 2026

Research and Development of High-performance Explosives

Research and Development of High-performance Explosives

Published on: February 20, 2016

Peptide Functionalized Nanoplasmonic Sensor for Explosive Detection.

Diming Zhang¹, Qian Zhang¹, Yanli Lu¹

¹1Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027 People's Republic of China.

Nano-Micro Letters

|November 23, 2018

Summary

This summary is machine-generated.

A novel nanobiosensor detects explosives like trinitrotoluene (TNT) with high sensitivity and selectivity. This peptide-based device utilizes localized surface plasmon resonance (LSPR) for accurate detection of chemical molecules.

Keywords:

2,4,6-trinitrotoluene (TNT)Localized surface plasmon resonance (LSPR)Nanocup arrays Nanosensor Peptide

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Area of Science:

Nanotechnology
Biosensing
Analytical Chemistry

Background:

Explosive detection remains a critical challenge in security and safety.
Existing methods often lack sensitivity, selectivity, or portability.
Development of rapid and accurate explosive detection systems is essential.

Purpose of the Study:

To develop a highly sensitive and selective nanobiosensor for the detection of 2,4,6-trinitrotoluene (TNT).
To utilize localized surface plasmon resonance (LSPR) for enhanced detection capabilities.
To demonstrate the sensor's ability to differentiate TNT from similar chemical compounds.

Main Methods:

Synthesized a peptide with a TNT-specific sequence.
Immobilized the peptide onto a nanodevice using Au-S covalent linkage.
Fabricated nanocup arrays and deposited gold nanoparticles for LSPR generation.
Monitored optical transmission spectra changes upon TNT binding.

Main Results:

Achieved high refractive index sensing sensitivity of approximately 10^4 nm/RIU.
Detected TNT at concentrations as low as 3.12 × 10^-7 mg/mL.
Demonstrated excellent selectivity, distinguishing TNT from 2,4-dinitrotoluene and 3-nitrotoluene.

Conclusions:

The developed peptide-based nanobiosensor offers a novel approach for sensitive and selective explosive detection.
LSPR-based nanodevices show significant potential for versatile chemical molecule sensing applications.
This technology could be applied to various security and safety monitoring systems.