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Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

Group Therapy

Group Therapy

Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Behavior Therapy

Behavior Therapy

Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...

Drug Therapy

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

Cognitive Therapy

Cognitive Therapy

Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...

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Related Experiment Video

Updated: Feb 2, 2026

Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos

Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos

Published on: May 12, 2020

Phage Therapy: Going Temperate?

Rodrigo Monteiro¹, Diana Priscila Pires¹, Ana Rita Costa²

¹CEB - Centre of Biological Engineering, University of Minho, Braga, Portugal.

Trends in Microbiology

|November 24, 2018

Summary

This summary is machine-generated.

Temperate phages, previously avoided for phage therapy due to gene transfer risks, are now being explored. Advances in technology offer new ways to use these phages against antibiotic-resistant bacteria.

Keywords:

CRISPR-Cas antibiotic resistance phage therapy synthetic biology temperate phages

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Area of Science:

Microbiology
Bacteriology
Virology

Background:

Strictly lytic phages are traditionally preferred for phage therapy.
Temperate phages have been avoided due to their potential to transfer genes, such as antibiotic resistance genes, between bacteria via specialized transduction.
This gene transfer can increase bacterial virulence and complicate treatment strategies.

Purpose of the Study:

To explore the therapeutic potential of temperate phages for treating bacterial infections.
To investigate how advances in sequencing and synthetic biology can enable the use of temperate phages.
To expand therapeutic options against the growing threat of antibiotic-resistant bacteria.

Main Methods:

Review of current literature on phage therapy and temperate phages.
Discussion of advancements in sequencing technologies relevant to phage research.
Exploration of synthetic biology approaches for engineering temperate phages.

Main Results:

New technologies are creating opportunities to overcome previous limitations associated with temperate phages.
Temperate phages can potentially be harnessed for therapeutic applications.
The use of temperate phages could significantly broaden the scope of phage therapy.

Conclusions:

Temperate phages, despite past concerns, show promise for phage therapy.
Technological advancements are key to unlocking the therapeutic potential of temperate phages.
Harnessing temperate phages offers a promising strategy to combat antibiotic-resistant bacterial infections.