Hidradenitis suppurativa and associated diseases

Area of Science:

• Dermatology
• Systemic Inflammatory Diseases
• Medical Comorbidities

Background:

• Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition.
• HS is characterized by recurrent abscesses, sinuses, and scarring, primarily in friction areas.
• Emerging evidence suggests HS is a systemic inflammatory disease with significant comorbidities.

Purpose of the Study:

• To review the current literature on diseases associated with hidradenitis suppurativa.
• To highlight the systemic nature of HS and its related health conditions.
• To emphasize the importance of considering comorbidities in HS management.

Main Methods:

• Literature review of diseases co-occurring with hidradenitis suppurativa.
• Analysis of recent studies defining HS as a systemic disease.
• Identification of common genetic, environmental, or inflammatory pathways linking HS and comorbidities.

Main Results:

• Metabolic disorders (obesity, metabolic syndrome) are highly prevalent in HS patients.
• Increased occurrence of autoimmune diseases (IBD, spondyloarthritis), autoinflammatory diseases, and genetic keratin disorders.
• Association with psychiatric diseases and increased risk of skin tumors noted.

Conclusions:

• Hidradenitis suppurativa is a systemic disease with a wide range of comorbidities.
• Management of HS requires a holistic approach addressing associated conditions.
• Understanding shared pathways is crucial for future therapeutic strategies.