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Adult Stem Cells for Regenerative Therapy.
Narasimman Gurusamy1, Abdulrhman Alsayari2, Sheeja Rajasingh3
1Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Progress in Molecular Biology and Translational Science
|November 25, 2018
Summary
Adult stem cells are key to tissue regeneration. This review explores their use in treating cardiac, brain, pancreatic, and eye disorders, highlighting their regenerative potential.
Area of Science:
- Regenerative Medicine
- Stem Cell Biology
Background:
- Adult stem cells, also known as somatic or resident stem cells, are undifferentiated cells residing in specialized niches within tissues.
- These cells are self-renewing, clonogenic, and multipotent, crucial for maintaining tissue homeostasis and repair after injury.
- Identified in various tissues, they possess regenerative capabilities demonstrated in preclinical and clinical studies.
Purpose of the Study:
- To review human therapies utilizing adult stem cells for regenerative purposes.
- To focus on the application of adult stem cells in treating cardiac, brain, pancreatic, and eye disorders.
Main Methods:
- Review of preclinical and clinical studies on adult stem cell therapies.
- Focus on specific types of adult stem cells, including hematopoietic stem cells and mesenchymal stromal/stem cells.
- Examination of therapeutic applications in distinct organ systems.
Main Results:
- Adult stem cells exhibit significant structural and functional regeneration capabilities.
- Various stem cell types, such as bone marrow-derived mononuclear cells and induced pluripotent stem cells, show therapeutic promise.
- Demonstrated potential for treating a range of disorders across different organ systems.
Conclusions:
- Adult stem cell therapy offers a promising approach for tissue regeneration and treating various diseases.
- Further research and clinical application are warranted to fully harness the potential of adult stem cells in human therapies.
- The review highlights the critical role of adult stem cells in regenerative medicine for complex disorders.
Keywords:
Blood disordersCardiospheresDiabetes mellitusMyoblastsNeurogenesisRegenerative therapyStem cellsStrokeMore Related Videos
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