Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Polymers02:34

Polymers

40.9K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
40.9K
Polymers02:34

Polymers

23.3K
23.3K
Molecular Shape and Polarity03:37

Molecular Shape and Polarity

75.7K
Dipole Moment of a Molecule
75.7K
VSEPR Theory and the Basic Shapes02:52

VSEPR Theory and the Basic Shapes

84.8K
Overview of VSEPR Theory
84.8K
System of Memory01:23

System of Memory

7.4K
Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
7.4K
Working Memory01:24

Working Memory

875
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
875

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Control of Cytocompatible Metallic and Polymeric Wrinkle Morphologies Using Programming via Printing (PvP).

ACS omega·2026
Same author

A Noncovalent Click-to-Release Strategy to Control Bond Cleavage and Prodrug Activation.

Angewandte Chemie (International ed. in English)·2026
Same author

Disrupted Sarcomere Reorganization of Cardiomyopathy-Prone Human iPSC-Derived Cardiomyocytes on a Dynamic Mechanical Substrate.

Cellular and molecular bioengineering·2025
Same author

Chemical Activation of Frontal Ring-Opening Metathesis Polymerization.

ACS macro letters·2025
Same author

High crystallinity and polar-phase content in electrospun P(VDF-TrFE) nanofibers with low molecular weight.

Journal of applied physics·2025
Same author

Author Correction: Controlled patterning of crystalline domains by frontal polymerization.

Nature·2025
Same journal

Injectable pH-responsive gelatin methacryloyl hydrogel for cuproptosis-syn ergized sunitinib therapy and immune reprogramming in clear cell renal cell carcinoma.

Acta biomaterialia·2026
Same journal

Corrigendum to "Injectable hydrogel-assisted local lipopolysaccharide delivery improves immune checkpoint blockade therapy" [Acta Biomaterialia 2025, 194, 153-168].

Acta biomaterialia·2026
Same journal

Enhanced Antithrombogenic Performance of Microfluidic Oxygenators through Dual Bioactive Surface Modification for an Artificial Placenta System.

Acta biomaterialia·2026
Same journal

Interface engineering to enhance properties of bioprosthetic heart valve materials with polysaccharide nanocomposite-conjugated hydrogels.

Acta biomaterialia·2026
Same journal

Thermoresponsive hydrogel for long-acting delivery of structurally intact and biologically active Fab fragment and monoclonal antibody.

Acta biomaterialia·2026
Same journal

Cell crowding initiates tumor invasion by triggering a nanoscale topography transition of plasma membranes.

Acta biomaterialia·2026
See all related articles

Related Experiment Video

Updated: Feb 2, 2026

Shape Memory Polymers for Active Cell Culture
10:53

Shape Memory Polymers for Active Cell Culture

Published on: July 4, 2011

13.9K

Enzymatically triggered shape memory polymers.

Shelby L Buffington1, Justine E Paul2, Matthew M Ali3

  • 1Department of Biomedical and Chemical Engineering, Syracuse University, 329 Link Hall, Syracuse, NY 13244, USA; Syracuse Biomaterials Institute, Syracuse University, 318 Bowne Hall, Syracuse, NY 13244, USA.

Acta Biomaterialia
|November 25, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel shape memory polymer (SMP) that responds to enzymatic activity, offering a new "smart material" for biomedical applications. This enzyme-responsive SMP enables isothermal shape changes, expanding possibilities for smart materials in research and development.

Keywords:
Enzyme responsive materialsShape memory polymersStimuli responsive materials

More Related Videos

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

13.5K
Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

19.3K

Related Experiment Videos

Last Updated: Feb 2, 2026

Shape Memory Polymers for Active Cell Culture
10:53

Shape Memory Polymers for Active Cell Culture

Published on: July 4, 2011

13.9K
Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

13.5K
Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

19.3K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Materials Engineering

Background:

  • Shape memory polymers (SMPs) are advanced smart materials typically activated by thermal or photothermal stimuli.
  • Existing SMPs lack direct triggering mechanisms responsive to biological activity, limiting their application in biological systems.
  • Development of SMPs that respond directly to biological cues is crucial for advanced biomedical research and translational applications.

Purpose of the Study:

  • To engineer a novel SMP that exhibits shape memory behavior directly triggered by enzymatic activity.
  • To achieve isothermal shape recovery under cell culture conditions for enhanced biocompatibility.
  • To evaluate the material properties, shape memory performance, and cytocompatibility of the enzyme-responsive SMP.

Main Methods:

  • Designed an SMP incorporating poly(ε-caprolactone) (PCL) as an enzymatically degradable shape-fixing component and Pellethane as a stable shape-memory component.
  • Conducted bulk enzymatic degradation experiments to analyze shape recovery through material contraction.
  • Performed quantitative and qualitative analyses of material properties, shape memory performance, and cytocompatibility.

Main Results:

  • Demonstrated successful shape recovery in SMPs triggered by enzymatic degradation of the PCL component.
  • Confirmed that shape recovery is achieved via the degradation of the shape-fixing phase.
  • Showcased the cytocompatibility of both the developed SMP materials and the enzymatic shape recovery process.

Conclusions:

  • The developed SMP is an enzyme-responsive material capable of programmed shape changes and mechanical force application.
  • This novel SMP design offers a direct biological activity-triggered response under isothermal conditions.
  • The material holds significant potential for new applications in materials science, particularly in stimulus-responsive systems for biomedical research.