Related Experiment Video
Updated: Feb 2, 2026
08:54
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
15.0K
Stereotactic Body Radiotherapy for Early-Stage Multiple Primary Lung Cancers
John Nikitas1, Todd DeWees2, Sana Rehman3
1Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO.
Clinical Lung Cancer
|November 28, 2018
Summary
Multiple courses of stereotactic body radiotherapy (SBRT) are safe and effective for patients with multiple primary lung cancers. These treatments show comparable overall survival and toxicity rates to single-course SBRT.
Area of Science:
- Oncology
- Radiation Oncology
- Thoracic Surgery
Background:
- Multiple primary lung cancers are increasingly treated with repeated stereotactic body radiotherapy (SBRT).
- The efficacy and safety of multiple SBRT courses require clarification.
Purpose of the Study:
- To evaluate the effectiveness and safety of single versus multiple courses of SBRT for stage I non-small-cell lung cancer.
- To compare outcomes including overall survival (OS), freedom from progression (FFP), and toxicity rates.
Main Methods:
- A review of a prospective lung SBRT database from June 2004 to December 2015.
- Analysis of patients receiving single-course SBRT, synchronous SBRT, metachronous SBRT alone, and surgery with metachronous SBRT.
Main Results:
- Metachronous SBRT (alone or with surgery) significantly improved OS and FFP compared to single-course SBRT.
- Synchronous SBRT showed similar OS and FFP to single-course SBRT.
- No significant differences in grade 3 or higher toxicity were observed across all groups.
Conclusions:
- Multiple SBRT courses, including synchronous and metachronous treatments, do not significantly increase toxicity.
- SBRT is a viable and safe treatment option for patients with multiple primary lung cancers, offering improved survival in metachronous cases.
Related Concept Videos
01:47Lung Capacity
56.3K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.3K
01:26Stages of Infection
65.2K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
65.2K
01:49Multiple Allele Traits
38.1K
The Concept of Multiple Allelism
38.1K
01:22Stages of General Anesthesia
1.7K
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
1.7K
01:22Stages of Sleep
1.4K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.4K
01:25Multiple Regression
4.0K
Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
4.0K