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Updated: Feb 2, 2026

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
Sustaining the Transition from a Petrobased to a Biobased Chemical Industry with Flow Chemistry
Romaric Gérardy1, Romain Morodo1, Julien Estager2
1Center for Integrated Technology and Organic Synthesis, Research Unit MolSys, University of Liège, 4000, Liège (Sart Tilman), Belgium.
Abstract:
In the current context of transitioning to more sustainable chemical processes, the upgrading of biobased platform molecules (i.e., the chemical transformation of widely available low molecular weight entities from biomass) is attracting significant attention, in particular when combined with enabling continuous flow conditions. The success of this combination is largely due to the ability to explore new process conditions and the perspective of facilitating seamless scalability while maintaining a small overall footprint. This review considers representative continuous flow processes which utilize a selection of currently popular platform molecules that target industrially relevant building blocks, including (a) commodity chemicals, (b) specialty and fine chemicals, and (c) fuels and fuel additives.
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