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Related Concept Videos

Local Attraction01:22

Local Attraction

387
Local attraction refers to disturbances in compass readings caused by magnetic influences from nearby objects such as metal fences, buried pipes, vehicles, buildings, power lines, or natural iron ore deposits. Small items like wristwatches, steel tools, or belt buckles can also interfere with the compass by creating local magnetic fields that distort the Earth's natural magnetic field. These distortions lead to inaccurate readings, posing navigation and land surveying challenges.Local...
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Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

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The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
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Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
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Absolute and Local Extreme Values01:22

Absolute and Local Extreme Values

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The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...
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Nuclear Localization Signals and Import01:46

Nuclear Localization Signals and Import

7.8K
Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of  2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...
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Local Anesthetics: Mechanism of Action01:23

Local Anesthetics: Mechanism of Action

3.3K
Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
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Is the local guy, just a local guy?

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  • 1Hospital Israelita Albert Einstein, Brazil.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
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Summary
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Systemic factors drive coronary atherosclerosis, but its effects often appear localized. A new study links stent failure to geometric changes in coronary arteries after implantation, highlighting local factors in cardiovascular disease.

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Coronary atherosclerosis is primarily driven by systemic risk factors.
  • Clinical presentation of atherosclerotic disease often mimics a localized process.
  • Stent implantation is a common intervention for coronary artery disease.

Discussion:

  • Zhang and co-workers investigated the link between stent failure and alterations in the 3D geometry of coronary segments post-implantation.
  • This study suggests that local geometric changes induced by stents may influence stent failure.
  • The findings challenge the purely systemic view of coronary atherosclerosis by emphasizing local factors.

Key Insights:

  • Stent implantation can induce significant changes in the 3D geometry of coronary segments.
  • These geometric alterations are associated with an increased risk of stent failure.
  • Local modulators play a crucial role in the pathophysiology and clinical outcomes of coronary atherosclerosis.

Outlook:

  • Further research into local modulators of coronary disease is warranted.
  • Understanding these local factors could lead to improved stent designs and implantation techniques.
  • This field holds significant promise for advancing cardiovascular research and patient care.